Research

 
 
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The Technology

The Phoenix Wound Matrix®, a fully resorbable, fibrous, 3D electrospun device composed of synthetic polymers, provides a temporary microenvironment that supports endogenous wound healing, allowing for regeneration and remodeling of native tissue in the defect space/wound bed.✧ This device is engineered to promote healthy tissue growth rather than a protracted inflammatory response.✧

For over a decade, Nanofiber Solutions, the technical parent company of RenovoDerm®, has worked with progressive surgeons and researchers to develop products designed to mimic the in vivo, microscopic, physical structures and properties of the extracellular matrix (ECM) vital to functional tissue regeneration.✧

To view Nanofiber Solutions’ wound scaffold poster, visit this link:

 
 
 

Cell Attachment/Migration

Multiple studies have shown that synthetic electrospun scaffolds can be created to possess the requisite properties known to promote functional tissue regeneration. Scaffolds with such properties allow cells to rapidly adhere, migrate, proliferate, and differentiate in a manner consistent with the body’s natural healing process.* Our devices are engineered to simulate the ECM properties found in target tissues, which promote and support the process of healthy tissue regeneration rather than that of protracted inflammation and fibrosis.✧

 

*Source Publications:

 
 
 
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Promoting Healing

The Phoenix Wound Matrix promotes healthy, functional tissue regeneration rather than protracted inflammation and fibrosis.✧ When the horse displayed here was initially evaluated following injury, the veterinarian recommended humane euthanasia due to the severity of the wound.  Instead, treatment with the Phoenix Wound Matrix was pursued at the owner’s request.  As a result of our groundbreaking technology, the horse made a full recovery.

 
 

 

Studies

 

GLP Animal Study:
Full Thickness Porcine Wound Model

Full thickness wounds measuring 2.0 cm in diameter were made in the backs of Yucatan miniature swine. The Phoenix Wound Matrix was applied to the wounds 48 hours after they were created. Following application, the wounds were bandaged with with:

  • a non-adherent application, followed by
  • sterile saline-soaked gauze, followed by
  • an outer Tegaderm film.

Following these applications, the animals were wrapped in bandaging to secure products.

Wounds were assessed by a veterinarian twice weekly (every 3-4 days), during which they were photographed, measured, and observed for evidence of healing, draining, signs of infection, and other notable observations. The non-adherent application, gauze, and Tegaderm were removed and replaced during each assessment.

Wounds were excised and processed for histological evaluation by a pathologist at days 14, 21, and 31. By day 31, the wounds were completely re-epithelialized. In addition to confirming complete epithelialization, histological evaluation validated mature granulation tissue and a receding inflammatory response.

Macroscopic images of a full thickness dermal wound treated with the Phoenix Wound Matrix at days 0, 14, 21, and 31 (left to right). Far right: microscopic image of wound histology at day 31 showing complete re-epithelialization, maturing of granulation tissue, and receding inflammatory response.

Macroscopic images of a full thickness dermal wound treated with the Phoenix Wound Matrix at days 0, 14, 21, and 31 (left to right). Far right: microscopic image of wound histology at day 31 showing complete re-epithelialization, maturing of granulation tissue, and receding inflammatory response.

 

Veterinary Case Study:
Equine Large Acute Traumatic Injury

The horse pictured below suffered a massive traumatic injury to its shoulder after colliding with a piece of farm equipment. The veterinarian initially recommended euthanasia due to the severity of the wound, however wound healing with the Phoenix Wound Matrix was pursued at the owner’s request.

The Phoenix Wound Matrix was applied shortly after the time of injury and reapplied periodically at the veterinarian’s discretion until the wound was healed. Four months after the injury, the wound was closed.

Excitingly, the Phoenix Wound Matrix prevented scarring and promoted growth of healthy new tissue with hair follicles, which is exceedingly difficult in horses.

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Nanofiber Solutions® designs and manufactures novel three-dimensional (3D) nanofiber scaffolds. Their platform technology mimics the extracellular matrix found within the body, providing a realistic environment for for all types of cells whether in the body or on a lab bench. To learn more about the platform technology that created The Phoenix Wound Matrix, click the link below.